1 Corinthians 16:21

The salutation of [me], Paul, with my own hand. Paul's letters were written by an amanuensis (Ro 16:22), but he always added a salutation in his own hand as a proof of genuineness (2Th 3:17). Spurious letters were circulated, as implied by 2Th 2:2.

Galatians 6:11

Ye see how large a letter I have written unto you with mine own hand. Rather as in the Revised Version: "See with how large letters". Paul used an amanuensis in letter writing, but the superscriptions were written in his own hand to show the genuineness of his epistles. See Ro 16:22 Col 4:18. Some have supposed that his "thorn in the flesh" (2Co 12:7) was a weakness of the eyes which rendered it difficult for him to write. See also Ga 4:15.

2 Thessalonians 3:17

With mine own hand. Here he adds the salutation in his own handwriting. The Epistle thus far had been written by one to whom he dictated, as was his custom, but he now adds his autograph.

Which is the token of every epistle. This autograph was proof of the genuineness. Their attention is perhaps called to this on account of a spurious epistle (2Th 2:2).
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