Mark 16:15

He said unto them. Probably not at the time referred to in Mr 16:14, but later. The Lord appeared many times during the forty days. These words may have been spoken at the great meeting in Galilee (Mr 16:7 Mt 28:18-20).

Go ye into all the world. Jesus is the world's Savior; he died for all; the gospel must be preached to all. In the first commission they were sent only to Jews (Mt 10:6).

Preach the gospel. The good news of salvation through Christ; the way of life.

To every creature. To every mortal. None are denied the Savior if they will have him.
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