Revelation of John 17:2

Have committed fornication; by their idolatrous devotion to her service.

Made drunk with the wine of her fornication; an allusion to the wine-cup which harlots give to their deluded votaries. The meaning is that the inhabitants of the earth have been deluded, corrupted, and made wretched by her errors, vices, and control. The wicked character and seductive influence of those who have been distinguished for their persecutions of God's people, he had represented under a great variety of images; all suited to show their detestable character, and lead all the right-minded to abhor them.
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